Depending on how long the Horizon environment has been around, you may want to check the message security mode. I don't recall exactly which version I was moving from or to, but made a fairly large jump in my environment not too long ago and the installer flagged my MIXED mode as being an issue. I successfully migrated to ENHANCED and completed the upgrade, but was a bit of surprise to have to work into the plans.
https://kb.omnissa.com/s/article/90251 - I didn't have a described failure post-upgrade, but otherwise discussion here is related.